Cutting-edge therapeutics derived from insights into diseased cellular behavior

WHO WE ARE

Level uP Pharmaceuticals operates as a rational, chemistry-driven platform that strategically leverages the intricate molecular bio-redox cell states inherent to malignant cancer cells. Our approach is centered around understanding and manipulating these cellular dynamics, aiming to pioneer innovative solutions in the quest for more effective and targeted cancer therapies.

ABOUT US

Our unique model in ground breaking discovery of novel cancer cure drugs is a path breaking assimilation of information derived from across various knowledge-based platforms of medicinal chemistry, redox chemistry, free radical biology, molecular cell biology, analytical chemistry, in vitro and in vivo biology that focus on eradicating cancer through targeted induction of necrosis.

Careers at Level Up Pharmaceuticals

Position: Scientist: Molecular/Cell Biologist

Job Type: Full Time

Position: Research Scientist / Scientist: Analytical Chemist

Job Type: Full Time

Position: Research Scientist / Scientist: Analytical Chemist

Job Type: Full Time

Job Summary:

We are seeking a highly skilled and motivated Analytical Chemist to join our team. The successful
candidate will be responsible for conducting various analytical tests and experiments to support our organization's objectives. The role requires expertise in analytical techniques, method development, data analysis, and a strong commitment to quality and precision.

Job Function:

The principal duties of this position are to develop robust analytical methods for the targeted and un- targeted small molecules identification, characterization, and quantification in the enzyme catalyzed reactions.

Job Duties:

The prerequisite expertise involves knowledge of conducting experiments and data analysis using high resolution mass spectrometry, enzyme activity assay and purification and characterization using an HPLC. We are looking for a candidate who is familiar with the Sciex triple quad 6500 and Q-Exactive Orbitrap mass spectrometers. The successful candidate is expected to work with various divisional teams effectively and contribute efficiently to the development of small molecules drugs for cancer treatment.

Sample Analysis:

Perform a wide range of analytical tests on various samples using state-of-the-art
analytical instruments, such as chromatographs, spectrometers, and mass spectrometers.

Method Development:

Develop and optimize analytical methods for the accurate quantification and
identification of chemical compounds in different sample matrices.

Sample Preparation:

Prepare and handle samples according to established protocols, ensuring the
integrity and proper documentation of samples.

Data Analysis:

Analyze and interpret data generated from experiments, maintaining accurate records,
and preparing comprehensive reports and documentation.

Quality Control:

Implement quality control and quality assurance procedures to ensure the accuracy and
reliability of analytical results.

Instrument Maintenance:

Maintain and troubleshoot analytical instruments, ensuring they are in
proper working condition.

Regulatory Compliance:

Ensure that all analytical work complies with relevant regulations, standards,
and safety protocols, and assist in regulatory submissions when necessary.

Collaboration:

Work collaboratively with cross-functional teams to provide analytical support for
research, product development, or other projects.

Research and Development:

Stay up-to-date with the latest advances in analytical chemistry and
contribute to the development of new analytical methods and technologies.

Qualifications:

A bachelo's, master's, or Ph.D. degree in chemistry, analytical chemistry, or a related field.Proven experience as an analytical chemist, preferably in an industrial or research setting.Proficiency in using various analytical instruments and techniques.Strong analytical and problem-solving skills.Excellent attention to detail and record-keeping abilities.Familiarity with laboratory safety protocols and practices.Strong communication and teamwork skills.Ability to work independently and manage multiple tasks and projects.Knowledge of relevant software for data analysis and instrument control.Preferred Qualifications (if applicable):Knowledge of industry-specific regulations and standards (e.g., GMP, GLP).Experience in method validation and transfer.Experience with specific analytical software or programming languages.We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

Position: Scientist: Molecular/Cell Biologist

Job Type: Full Time

Job Function:

The deserving applicant is required to be an expert in key concepts of cellular and molecular biology mechanisms and can apply independent research ideas and communicate them effectively to diverse teams for the novel development of small molecule-based therapeutics. In-depth knowledge of mitochondrial energetics and function-activity correlation of mitochondrial sub-particles is highly desirable. The candidate is responsible, in a collaborative way, for planning, executing, record-keeping, and presenting cellular imaging studies proactively to provide knowledge and promote a robust scientific culture. Hands-on experience in the study of autocrine and paracrine signaling mechanisms is an added advantage.

Job Duties:

The selected candidate is anticipated to participate in the project planning and successful completion of result-oriented multi-level research in drug advancement. The applicant is expected to demonstrate a strong desire for the exchange of ideas and advice across broad research areas within the company. Excellent bookkeeping, analysis, communication skills, and presentations to the teams are necessary.

Experiences:

Experience in conducting tissue culture experiments using a variety of macular and cell biology techniques.A solid background in confocal microscopy, fluorescent-based techniques like fluorescence energy transfer (FRET), fluorescence lifetime imaging (FLIM), and Fluorometric Imaging Plate Readers (FLIPR).Experience in hypoxic chambers, live cell imaging, and analysis using Incucyte.Knowledge of mitochondrial disorders and reprogramming related mechanisms.Exceptional experience with Seahorse analyzer and mitochondrial energetics.A solid background in mitochondrial function and cellular energetics.Research experience in patch clamp techniques is an additional but not a must requirement.Basic computer skills (Word, Excel, and PowerPoint) including PRISM/GraphPad.A plus would be experience with R or Python.

Education:

Ph.D. or equivalent experience in Cell/Molecular Biology with at least 2 years of industrial research experience.We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.